Effect of 2-Nitropropane on Chemical Neurotransmission, Spontaneous and Evoked, in the Sartorius Muscle of the Frog

Organic solvents are chemically different compounds with one common feature: They dissolve fats, oils, resins, cellulose, acetate, and cellulose nitrate, which makes them widely used in industry. Most often organic solvents are used in paint and lacquer industries, in production of pesticides, explosives, plastic, rubber, cellulose, air conditioners, in pharmaceutical industry, and in leather industry [1]. Millions of people around the world are exposed to industrial organic solvents in the manufacturing sectors. Some individuals drink solvents, for example alcohol dependence and alcohol abuse or harmful use cause substantial morbidity and mortality [2]. Solvents are neurotoxic substances that are detrimental to the functioning of the nervous system [3-5]. High-level occupational exposure to volatile organic solvents may elicit various neurotoxic effects [6]. It has previously been shown that some solvents modulate inhibitory transmission and affect synaptic transmission [7,8].